LACTAM-CONTAINING TETRAHYDRO-PYRAZOLO 3,4-C PYRIDINE COMPOUNDS USEFUL AS FACTOR XA INHIBITORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME FOR TREATING THROMBOEMBOLIC DISORDERS

摘要

The present application describes lactam-containing compounds and derivatives thereof of Formula I: P 4 -P-M-M- 4 or pharmaceutically acceptable salt forms thereof, wherein ring P, if present is a 5-7 membered carbocycle or heterocycle and ring M is a 5-7 membered carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.