derivatives of 6 - (6) - o - substituted - benzothiazole and benzimidazole triazolopyridazine - sulfanyl): preparation, application as medicines and use as inhibitors of

摘要

THE INVENTION CONCERNS THE NEW PRODUCTS OF FORMULA (I): (I) IN WHICH (II) REPRESENTS A SINGLE OR DOUBLE LINK; RA REPRESENTS -O-Z-RC WITH SINGLE LINK OR POTENTIALLY SUBSTITUTED ALKYLENE AND RC REPRESENTS CYCLOALKYL, HETEROCYCLOALKYL, ARYLE OR POTENTIALLY SUBSTITUTED HETERARYL; RB REPRESENTS H OR F; WITH IF RB IS H, THEN RC IS NOT CYCLOALKYL WHEN Z IS SIMPLE LINK AND RC IS NOT HETEROCYCLOALKYLE WHEN Z IS ALKYLENE; X REPRESENTS S, SO OR SO2, A REPRESENTS NH OR S; W REPRESENTS H, ALKYLE, CYCLOALKYLE OR COR WITH R REPRESENTS CYCLOALKYLE; ALKYLE; ALCOXY; O- PHENYL; -O- (CH2) N-PHENYL WITH N = 1 TO 4;Or NR1 R2 and R1 represent h or ALK and R2 represent h, naphthenic or alkyl; or R1, R2 form a cycle that may include o, s, N and / or NH; all of these radicals may be substituted; these products act as drugs, including all isomeric forms and salts that act as met inhibitors.