HUMAN ANTIBODIES TO HUMAN ANGIOPOIETIN-LIKE PROTEIN 4.

摘要

A fully human antibody or antigen -binding fragment of a human antibody that specifically binds and inhibits human angiopoietin - like protein 4 (hANGPTL4) is provided. The human anti- hANGPTL4 antibodies are useful in treating diseases or disorders associated with ANGPTL4, such as hyperlipidemia, hyperlipoproteinemia and dyslipidemia, including hypertriglyceridemia, hypercholesterolemia, chylomicronemia, and so forth. Furthermore, the anti -hANGPTL4 antibodies can be administered to a subject in need thereof to prevent or treat diseases or disorders, for which abnormal lipid metabolism is a risk factor. Such diseases or disorders include cardiovascular diseases, such as atherosclerosis and coronary artery diseases; acute pancreatitis; nonalcoholic steatohepatitis (NASH); diabetes; obesity.