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Piperidinyl, indolyl, pirinidyl, morpholinyl and benzimidazolyl urea derivatives as inhibitors of soluble epoxide hydrolase for the treatment of hypertension, inflammations and other diseases
Piperidinyl, indolyl, pirinidyl, morpholinyl and benzimidazolyl urea derivatives as inhibitors of soluble epoxide hydrolase for the treatment of hypertension, inflammations and other diseases
Disclosed is a piperidine compound of formula (I) where the substituents are as disclosed in the specification. Examples of compounds of the invention are: 1-(1-acetyl-piperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea, 1-(1-trifluoromethylcarbonylpiperidin-4-yl)-3 -(4-trifluoromethoxyphenyl)urea and N-(1-methanesulfonylpiperidin-4-yl)-N'-(4-trifluoromethoxyphenyl)urea. Also disclosed is a pharmaceutical composition comprising a compound of formula (I), an in vitro method for inhibiting a soluble epoxide hydrolase and the use of a compound of formula (I) in the manufacture of a medicament for treating a disease modulated by soluble epoxide hydrolases for example hypertension, inflammation, adult respiratory distress syndrome; obstructive pulmonary disease; interstitial lung disease; asthma; diabetic complications; end stage renal disease; renal deterioration; nephropathy; Raynaud syndrome and arthritis. The compounds are also useful for treating conditions responsive to regulation of endothelial cell function.
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