Piperidinyl, indolyl, pirinidyl, morpholinyl and benzimidazolyl urea derivatives as inhibitors of soluble epoxide hydrolase for the treatment of hypertension, inflammations and other diseases

摘要

Compounds of the formula (I); wherein R is a member selected from the group consisting of C-Calkyl, arylC-Calkyl, C-Ccycloalkyl and heterocyclyl, Y is selected from the group consisting of a bond, C(R), NR and O; Y is selected from the group consisting of a bond, NR and O; each R, R and R is independently selected from the group consisting of H, alkyl and COR; A is heterocyclyl, optionally substituted with from 1 to 2 R substituents; L is selected from the group consisting of a direct bond, C-Calkylene, CCheteroalkylene, C-Ccycloalkylene, arylene, heteroarylene, -CO-, -SO- and -Se-; R is selected from the group consisting of H, CCalkyl, C-Calkenyl, C-Calkynyl, C,-Cheteroalkyl, arylC-Calkyl, CC,cycloalkyl and heterocyclyl, are claimed. The compounds are inhibitors of the soluble epoxide hydrolase (sEH) and useful for the treatment of hypertension, inflammation, adult respiratory distress syndrome; diabetic complications; end stage renal disease; Raynaud syndrome and arthritis.