Disclosed is polypeptide for modulating mast cell activation, said polypeptide comprising a NEDD 9 Src homology 3 (SH3) domain sequence that consists of a sequence as set forth in SEQ ID NO: 8 or a variant or fragment thereof wherein: (i) the variant consists of a sequence as set forth in anyone of SEQ ID NOs: 16, 33-49,145-148, 156-159, 165-168, or 176-179; and (ii) the fragment consists of a sequence as set forth in anyone of SEQ ID NOs: 122-125, or 134-137. Also disclosed is the use of a polypeptide comprising a NEDD9 Src homology 3 (SH3) domain ammo acid sequence for the manufacture of a medicament for the treatment of a hypersensitivity disease or disorder arising from mast cell activation
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机译：公开了用于调节肥大细胞活化的多肽，所述多肽包含NEDD 9 Src同源性3（SH3）结构域序列，该序列由SEQ ID NO：8所示的序列或其变体或片段组成，其中：（i）所述变体由SEQ ID NO：16、33-49、145-148、156-159、165-168或176-179中任何一个所示的序列组成; （ii）该片段由SEQ ID NO：122-125或134-137中任何一个所示的序列组成。还公开了包含NEDD9 Src同源性3（SH3）结构域氨酸序列的多肽在制备用于治疗由肥大细胞活化引起的超敏性疾病或病症的药物中的用途。
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