Phthalazinone derivatives for ibhibiting the activity of the enzyme poly (ADP-ribose)polymerase-1 (PARP-1)

摘要

A phthalazinone derivative compound of the formula (I) is disclosed, wherein: A and B together represent an optionally substituted, fused aromatic ring; X and Y are selected from CH and CH, CF and CH, CH and CF and N and CH respectively; Rc is selected from H, C1-4 alkyl; and R1 is selected from C1-7 alkyl, C3-20 heterocydyl and C5-20 aryl, which groups are optionally substituted. These compounds are useful in the preparation of a medicament for inhibiting the activity of PARP for the treatment of : vascular disease; septic shock; ischaemic injury; neurotoxicity; haemorraghic shock; viral infection; or for use as an adjunct in cancer therapy or for potentiating tumour cells for treatment with ionizing radiation or chemotherapeutic agents.