Arilados CAMPHENE with activity on cb2 receptors and processes for their Preparation

摘要

Referring to CAMPHENE Derivative of formula (i), where the dashed line represents a Single Bond or double; ra is alkyl alquenilo C1 - C5, C2 - C5, C2 - C5 alquinilo, among others; RB and rc h, o or s, =, =, among others. Preferred compounds are: Methyl 2 - (4 - (2,6 - Dimethoxy - 2 - 2 - metiloctan - il) phenyl) - 7.7 - dimetilbiciclo [2.2.1] hept-3-ene - 2 - in - 1 - carboxylate (2.6 - Dimethoxy - 2 - 4 - (2 - metiloctan - 2 - il) phenyl) - 1,7,7-trimethylbicyclo [2.2.1] hept-2-ene acid, 2 - (2,6 - Dimethoxy - 2 - pentyl phenyl) - 7.7 - dimetilbiciclo [2.2.1] hept-3-ene - 2 - in - 1 - carboxylic acid, among others. It also relates to a Pharmaceutical Composition and a preparation method.These compounds have activity on the CB2 cannabinoid Receptors and are useful in the treatment of Liver Diseases, inflammation, diabetes, Brain injuries, among others