PROCESS FOR THE PREPARATION OF A SUBSTANCE WITH ANTITUMOR ACTIVITY 1,1'-(2'-BROMO-2'-CHLOROETHENYL)-BIS-(BENZIMIDAZOLE)

摘要

A process for the preparation of a substance with antitumor activity 1,1'-(2"-bromo-2"-chloroethenyl)-bis-(benzimidazole) by interaction of benzimidazole with halothane (molar ratio of 2:1.5) in the system of solvents (benzene-dimethylformamide) under conditions of phase-transfer catalysis with dibenzo-18-crown-6-ether in the presence of potassium hydroxide.