Preparation of Folate-decorated Hydroxycamptothecin Nanoparticle Lyophilized Powder and Its Antitumor Activity on Mice bearing S180

摘要

Nanoparticle lyophilized powder of HCPT/CTS-TPP-FA was prepared with hydroxycamptothecin(HCPT) as model drug, folate(FA) as targetting ligand, chitosan(CTS) as carrier, sodium tripolyphosphate(TPP) as polyanion and mannitol as cryoprotectant. The antitumor activity of HCPT/CTS-TPP-FA on mice bearing S180 was investigated. The results indicated that the lyophilized powder dispersed quickly into homogeneous emulsion colloid without any suspended substance in distilled water, glucose injection and normal saline. HCPT/CTS-TPP-FA and HCPT/CTS-TPP could both inhibit the growth of S180 tumor cells of mice, and the difference is significant (P<0.01).The inhibition rate of HCPT/CTS-TPP-FA(52.91%) is better than that of HCPT/CTS-TPP(40.06%).