USE OF ALQUILFOSFOCOLINAS IN COMBINATION WITH ANTITUMORAL MEDICINES.

摘要

Use of alkyl phosphocholines of the general formula II wherein, independently of each other: n, m, p, z means an integer between 0 and 4; X means O, S, NH; R means H, a straight or branched C1-C20 alkyl radical, which may be saturated or unsaturated with one to three double and / or triple bonds, and which may be unsubstituted or optionally substituted in the same or in different C atoms with one, two or more halogen, nitro, cyano, hydroxy, C1-C6 alkoxy, amino, mono (C1-C4 alkyl) -amino or di (C1-C4 alkyl) -amino radicals; R1, R2 independently of one another, mean H, a straight or branched C1-C6 alkyl radical, preferably methyl and ethyl, a C3-C7 cycloalkyl radical, and which may be unsubstituted or optionally substituted in the same or in different C atoms with one, two or more halogen, nitro, cyano, hydroxy, C1-C6 alkoxy, amino, mono (C1-C4 alkyl) -amino or di (C1-C4 alkyl) -amino radicals , to prepare a medicament for the treatment of benign and malignant tumor diseases before and / or during treatment with an approved antitumor drug, which is an antimetabolite.