TRICYCLIC PIRIDINE DERIVATIVES, MEDICATIONS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCEDURE FOR PREPARATION.

摘要

A compound of formula I wherein R1 is phenyl substituted with R11 and / or R12 and / or R13 or pyridyl substituted with R11 and / or R12 and / or R13, where R11 is halogen, cyano, C1-4 alkyl, C3 cycloalkyl -7, C3-7 cycloalkyl-C1-4 alkyl, C3-7 cycloalkoxy, C3-7 cycloalkyl-C1-4 alkoxy, C1-4 alkoxy, C1-4 alkyl substituted completely or partially with fluorine or C1-4 alkoxy substituted completely or partially with fluorine, R12 is halogen, cyano, C1-4 alkyl, C1-4 alkoxy, C1-4 alkyl substituted completely or partially with fluorine or C1-4 alkoxy substituted completely or partially with fluorine, R13 is halogen, R2 is hydrogen or C1-4 alkyl, R3 is hydrogen or C1-4 alkyl, or R2 and R3 together, and including the carbon atom to which they are attached, form a C3-7 cycloalkane ring, said C3-7 cycloalkane ring being optionally substituted with halogen, cyano, C1-4 alkyl, C1-4 alkoxy, C1-4 alkyl completely or partially substituted with fluorine or C1-4 alkoxy substituted completely or partially c on fluorine, R4 is hydrogen or C1-4 alkyl, R5 is hydrogen or C1-4 alkyl, or R4 and R5 together, and including the carbon atom to which they are attached, form a C3-7 cycloalkane ring, said ring being C3-7 cycloalkane optionally substituted with halogen, cyano, C1-4alkyl, C1-4alkoxy, C1-4alkyl completely or partially substituted with fluorine or C1-4alkoxy completely or partially substituted with fluorine, R6 is hydroxyl, halogen, alkoxy C1-4 or C1-4 alkoxy substituted completely or partially with fluorine, R7 is hydrogen or C1-4 alkyl, or R6 and R7 taken together and with the carbon atom to which they are attached, form a carbonyl group ( C = O ) or oxime ( C = N-OH), R8 is C1-9 alkyl, R80 or R80-C1-4 alkyl, where R80 is C3-7 cycloalkyl, C3-7 cycloalkenyl, 3 to 7 membered heterocycloalkyl, heterocycloalkenyl of 3 to 7 members, 5 or 6 membered phenyl or heteroaryl, wherein said R80 is optionally substituted with R81 and / or R82, where R81 is halogen, cyano, alkyl C1-4, C3-7 cycloalkyl, C1-4 alkoxy, C3-7 cycloalkoxy, C1-4 alkylcarbonyl, C1-4 alkoxycarbonyl, C1-4 alkyl substituted completely or partially with fluorine or C1-4 alkoxy completely or partially substituted with fluorine, wherein each of said C1-4alkyl, C1-4alkoxy, C1-4alkylcarbonyl and C1-4alkoxycarbonyl may be optionally substituted with R810, where R810 is C3-7 cycloalkyl, C3-7 cycloalkenyl, 3 to 3 heterocycloalkyl 7 members, 3 to 7 membered heterocycloalkenyl, 5 or 6 membered phenyl or heteroaryl, wherein said R810 is optionally substituted with R811 and / or R812, where R811 is halogen, cyano, C1-4 alkyl, C1-4 alkoxy, alkyl C1-4 completely or partially substituted with fluorine or C1-4 alkoxy substituted completely or partially with fluorine R812 is halogen, cyano, C1-4 alkyl, C1-4 alkoxy, C1-4 alkyl completely or partially substituted with fluorine or C1- alkoxy 4 completely or partially substituted with fluorine R82 is halogen, cyano, C1-4 alkyl, alkoxy C1-4, C1-4 alkyl completely or partially substituted with fluorine or C1-4 alkoxy substituted completely or partially with fluorine, tautomers, stereoisomers, mixtures thereof and salts thereof