DNA comprising at least a promoter sequence that is derived from a wild type promoter of Hansenula polymorpha, which is selected from the group consisting of the MOX, FMD and TPS1 promoter, wherein transcription efficiency of this promoter sequence is modulated by modifying a DNA binding site compared to the efficiency of the wild type promoter, in which case the modification is effected by palindromización of at least one of the DNA sequences according to SEQ ID No: 1-4, 11, 13, 16 and 20, in which case the sequence palindromizada deviates no more than 2 bases fully palindromizada chain sequence.
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机译：包含至少一个来源于多形汉逊酵母野生型启动子的启动子序列的DNA，该启动子序列选自MOX，FMD和TPS1启动子，其中该启动子序列的转录效率通过修饰DNA结合位点来调节与野生型启动子的效率相比，在这种情况下，修饰是通过palindromización对至少一个根据SEQ ID No：1-4、11、13、16和20的DNA序列进行的，在这种情况下，该序列palindromizada偏离完整palindromizada链序列的碱基不超过2个。
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