chimeric and humanized antibodies integrin alpha 5 beta 1 modulate angiogenesis

摘要

chimeric or humanized anti-α5ß1 comprising integrin antibody: - a region of variable heavy chain with a sequence selected from the group consisting of SEQ ID NOs: 25, 28, and 31 as defined respectively in Figures 10, 11 and 13; and - a region of a variable light chain sequence selected from the group consisting of SEQ ID NOs: 26 and 32 as defined in Figures 10 and 13 respectively