CHIMERIC AND HUMANIZED ANTIBODIES TO ALPHA5 BETA1 INTEGRIN THAT MODULATE ANGIOGENESIS

摘要

The present invention provides chimeric and humanized antibodies that specifically recognize alpha5beta1 integrin, and methods for using the antibodies for reducing or inhibiting angiogenesis in a tissue. Also provided are methods of determining therapeutically acceptable doses of the antibodies and pharmaceutical compositions including the same.