DIAGNOSIS AND TREATMENT OF NEUROECTODERMAL TUMORS

摘要

The present invention provides fusion proteins for the detection and treatmentof neuroectodermal tumors. Previous work demonstrated that chlorotoxin isspecific for glial-derived or meningioma-derived tumor cells. The currentinvention has extended the use of chlorotoxin-cytotoxin fusion proteins totreat the whole class neuroectodermal tumors such as gliomas, meningiomas,ependymonas, medulloblastomas, neuroblastomas, gangliomas, pheochromocytomas,melanomas, PPNET's, small cell carcinoma of the lung, Ewing's sarcoma, andmetastatic tumors in the brain. Also, diagnostic methods are provided forscreening neoplastic neuroectodermal tumors.