LCMV-GP-VSV PSEUDOTYPED VECTORS AND TUMOR INFILTRATING VIRUS-PRODUCING CELLS FOR THE THERAPY OF TUMORS

摘要

The invention relates to recombinant VSV viruses and viral vectors whichproduce aglycoprotein GP of the lymphocyte choriomeningitis virus (LCMV) instead of theG protein of theVSV, to virus producing cells which produce LCMV-GP-pseudotyped VSV virions,and to theuse of said vectors and cells in the therapy of solid tumors, especially braintumors.