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Compounds for inhibition of 5-hydroxytryptamine and norepinephrine reuptake or for treatment of depression disorders, their preparation processes and uses thereof
Compounds for inhibition of 5-hydroxytryptamine and norepinephrine reuptake or for treatment of depression disorders, their preparation processes and uses thereof
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机译:用于抑制5-羟色胺和去甲肾上腺素再摄取或用于治疗抑郁症的化合物,其制备方法和用途
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摘要
Compounds of the general formula (I), optical isomers, pharmaceutically acceptable salts, preparation process and uses thereof in which R1, R2, R3 and R4 are as defined in specification are disclosed. Such compounds can be optical isomers or racemic mixtures and can be metabolically transformated into 1-[2-dimethylamine-1-(4-hydroxyphenyl)-ethyl]cyclohexanol with new pharmaceutically active in vivo after administration, which can be used for treating diseases associated central nervous system such as depression et al. by interrupting reuptake of 5-hydroxytryptamine (5-HT ) and norepinephrine (NA ) .
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