RNA interference mediated inhibition of Aurorakinase B and its combinations as anticancer therapy

摘要

This invention relates to the use of short nucleic acid molecules that modulateAurora-B kinase (AurkB) expression. The invention includes compounds, compositionsand methods useful for the modulation of expression and activity of genes involvedin the AurkB pathway. In one embodiment, the present invention provides shortnucleic acid molecules, such as siRNA, which can be used in treating, preventing,or inhibiting cancer, and any other proliferative disease, trait or condition,which respond to a reduction in AurkB expression in a cell or tissue. Such shortnucleic acid molecules can be used alone or in combination with other treatmentsor therapies, including short nucleic acid molecules that modulate expressionof EGFR.