USE OF IgM ANTIBODIES AGAINST dsDNA IN SYSTEMIC LUPUS ERYTHEMATOSUS WITH NEPHRITIS

摘要

A method for the production of a means for treating or preventing systemic lupus erythematosus is disclosed. Said means comprises IgM for sub-cutaneous and/or intra-muscular application. A preferred IgM is autoantigen IgM, in particular anti-ds-DNA and anti-phospholipid IgM. A pharmaceutical combination package for treatment of SLE is also disclosed, containing the IgM antibodies, together with at least one anti-inflammatory agent, at least one immuno-suppressive agent and/or at least one cytostatic agent for simultaneous and/or serial application.