STABILIZED SOLUTION OF ORTHO-SILICIC ACID BASED ON SALICYLIC ACID AS EFFECTIVE INHIBITOR OF ITS POLYMERIZATION, ITS PREPARATION AND USE

摘要

The present invention discloses a formulation that serves as a highly bioavailable silicon (Si) source consisting of: (i) ortho-silicic acid (H₄SiO₄), from 0.01-8% w/w; (ii) salicylic acid (1), from 1-2 molar equivalents to H₄SiO₄; (iii) pharmaceutically acceptable acid, from 0.1-4 molar equivalents to H₄SiO₄; or pharmaceutically acceptable base, in amounts of 2 molar equivalents to salicylic acid (1); and (iv) diluent, selected from the group consisting of: purified water, 1, 2-propylene glycol, glycerol, ethanol, or their mixtures, in amounts of up to 100% w/w of the formulation. The present invention discloses the preparation and the use of the formulation that provides all known positive therapeutic effects of ortho-silicic and salicylic acid in human and animals, and benefits of use for plants.