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CYCLIZED NON-NATIVE SYNTHETIC PEPTIDE AND COMPLEX OF PEPTIDES COMPRISING SAID CYCLIZED PEPTIDE, INTENDED TO INDUCE AND TO CHARACTERIZE THE PREVENTION OR TREATMENT OF CONDITIONS IN MAMMALS
CYCLIZED NON-NATIVE SYNTHETIC PEPTIDE AND COMPLEX OF PEPTIDES COMPRISING SAID CYCLIZED PEPTIDE, INTENDED TO INDUCE AND TO CHARACTERIZE THE PREVENTION OR TREATMENT OF CONDITIONS IN MAMMALS
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机译:循环的非天然合成肽和包含所述循环的肽的肽复合物,旨在诱导和表征哺乳动物的病情预防或治疗
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摘要
Non-native synthetic peptide cyclized by means of a disulphide bridge, characterized by the amino acid sequence (E34P) that follows (SEQ ID No. 1): E-D-E-H-K-G-K-Y-C-R-L-G-N-D-C-R-T-T-E-P-T-T-T-A-T-P-R-G-T-P-T-P-A-P and a complex of non-native synthetic peptides that is intended to induce and characterize the prevention and/or treatment of conditions in mammals, the protective immunity of which depends on the stimulation of Th1 type lymphocytes, and, in particular, on a state of delayed hyperstimulation, containing: said peptide (E34P), the following sequence (A16E) of 16 amino acids (SEQ ID No. 2) or derivatives (structural analogues) thereof: A-A-R-C-A-R-C-R-E-G-Y-S-L-T-D-E the following sequence (A16G) of 16 amino acids (SEQ ID No. 3) or derivatives (structural analogues) thereof: A-A-S-S-T-P-S-P-G-S-G-C-E-V-D-G, and an adjuvant which preferably induces a cell-mediated response.
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机译:通过二硫键环化的非天然合成肽,其特征在于其后的氨基酸序列(E34P)(SEQ ID No. 1):EDEHKGKYCRLGNDCRTTEPT-TTATPRGTPTPAP和非天然合成肽的复合物,旨在诱导和诱导表征哺乳动物疾病的预防和/或治疗,其保护性免疫取决于Th1型淋巴细胞的刺激,特别是延迟过度刺激的状态,其包含:所述肽(E34P),以下序列( 16个氨基酸(SEQ ID No. 2)或其衍生物(结构类似物)的A16E):AARCARCREGYSLTDE以下16个氨基酸(SEQ ID No. 3)或其衍生物(结构类似物)的序列(A16G):AASSTPSPGSGCGCEVDG,和优选诱导细胞介导的应答的佐剂。
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