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NOVEL CYCLOSPORIN A HYDROXYLASE GENE OF SEBEKIA BENIHANA

机译：新型环孢菌素本氏菌的羟化酶基因

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摘要

The present invention relates to a novel cyclosporin A hydroxylase derived from Sebekia benihana, to a gene (CYP21) coding for the enzyme, to a recombinant expression vector cloned by the gene coding for the enzyme, and to a transformant which has been genetically transformed by means of the recombinant expression vector. CYP21 is a novel gene that has not been previously reported and is a CYP gene that is specific to cyclosporin A. The cyclosporin A hydroxylase of the present invention can be used to advantage in immune reactions involving cyclosporin A by being produced in volume by means of genetic recombination. 展开▼

机译：本发明涉及一种衍生自 Sebekia benihana 的新型环孢菌素A羟化酶，涉及编码该酶的基因（CYP21），涉及通过编码该酶的基因克隆的重组表达载体，并且涉及已经通过重组表达载体遗传转化的转化子。 CYP21是以前没有报道过的新基因，并且是对环孢菌素A具有特异性的CYP基因。本发明的环孢菌素A羟化酶可以通过如下方法大量生产而用于涉及环孢菌素A的免疫反应中。基因重组。 ~~展开▼~~

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公开/公告号WO2012096421A1

专利类型

公开/公告日2012-07-19

原文格式PDF

申请/专利权人 CHABIO&DIOSTECH CO. LTD.;HAN KYU-BOEM;KIM EUNG-SOO;LEE MI-JIN;KIM HYUN-BUM;
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申请/专利号WO2011KR00275

发明设计人 HAN KYU-BOEM;KIM EUNG-SOO;LEE MI-JIN;KIM HYUN-BUM;
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申请日2011-01-14

分类号C12N9/02;C12N15/53;C12N15/63;

国家 WO

入库时间 2022-08-21 17:14:43

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