EFFICIENT OPTICAL ARRANGEMENT FOR ILLUMINATION AND DETECTION OF LABEL-FREE BIOSENSORS AND METHOD TO REDUCE INTERFERENCE FRINGES IN LABEL-FREE IMAGING

摘要

An optical arrangement for illuminating a surface of a biosensor is described The biosensor is preferably a sensor having periodic surface grating structure The arrangement includes a light source generating light, collimating optics for collimating the 5 light from the light source, and first reflecting surface receiving light from the collimating optics and directing incident light onto a surface of the biosensor and a second spatially separated reflecting surface receiving light reflected from the surface of the biosensor The arrangement further includes telecentric optics (e g, telecentric lens) receiving light from the second surface of the prism The telecentric lens directs light onto an entrance 10 slit of a spectrometer The arrangement increases the light collection efficiency at the spectrometer as compared to pπor art to pπor art arrangements