CYCLIC PEPTIDE CYCLO (L -ARGINYL - GLYCYL - L -ASPARTYL - D - PHENYLALANYL - N-METHYL - L -VALYL), COMPOSITIONS THEREOF, AND USE THEREOF IN METHODS FOR TREATING GRAFT -VERSUS - HOST DISEASE

摘要

The instant invention relates to compounds, compositions and methods are provided for prevention and treatment of various forms of graft-versus-host disease (GvHD) comprising or using Cilengitide, a cyclic arginine-glycine- aspartic acid containing pentapeptide, and/or pharmaceutically acceptable dervatives, solvates and/or salts thereof. Moreover, various dosing regimens and/or combinations comprising or using Cilengitide and/or pharmaceutically acceptable dervatives, solvates and/or salts thereof are provided, preferably for the treatment of humans in vivo and preferably as well for ex vivo conditioning of organ transplants in order to suppress immune responses and preferably also other adverse effects resulting in GvHD and related inflammatory processes.