Method of preparation of new polypeptides, in particular of tétracosapeptides of formula 1 - seryl - 1 - tyrosyl - 1 - seryl - 1 - (chi) - 1 - glutamyl (or glutaminyl -) - 1 - histidyl - 1 - phenylalanyl - 1 - arginyl - 1 - tryptophyl - glycyl - 1 - lysyl - 1 - prolyl - 1 - valyl - glycyl - 1 - lysyl - 1 - arginyl - 1 - arginyl - 1 - propyl - 1 - valyl - 1 - lysyl - 1 - valyl - the proline tyrosyl l - - -

摘要

(A) A process for manufacture of tetracosapeptides of formula (I) L-Seryl-L-tyrosyl-L-seryl-L-methionyl-L-X-L-histidyl-L-Phalanyl-L- -arginyl-L-tryptophyl-glycyl-L-lysyl-L-prolyl-L-valyl-glycyl-L-ly- syl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-valyl-L-lysyl-L-valyl-- L-tyrosyl-L-proline. X = radical of glutamine or glutamic acid, their derivs., acid addition salts and complexes of Cu, Co or pref. Zn. Derivs. are all functional, e.g. esters, amides, hydrazides, N-acyl, or cpds. contng. other NH2-protecting groups, e.g. trityl, carbobenzoxy (opt. substd.) etc.