METHOD FOR ANALYZING THE RISK OF HEPATOMA ONSET FOR CHRONIC PATIENTS OF HEPATITIS TYPE B, AND METHOD OF PREDICTING SAME

摘要

According to the present invention, the aspects of increased frequency of generated mutations in hepatitis type B virus which infect a patient group with chronic hepatitis type B and a patient group whose chronic hepatitis type B progresses to hepatoma on the X gene and precore/core gene, are analyzed through various molecular genetic analysis methods. Then, markers for predicting hepatoma on the X gene and precore/core gene, independently concerned with the onset of the hepatoma, are derived. The present invention relates to a highly sensitive and highly specific analyzing method of hepatoma onset risk for a chronic patient of hepatitis type B and a method of predicting same by using a mutation pattern, that is, a mutation accumulating number and/or combination of the markers for predicting the hepatoma.