首页> 外国专利> Tolerance induction or immunosupression to prevent in particular Graft-versus-Host-Disease (GvHD) by short-term pre-incubation of transplanted cell suspensions, tissues or organs coated with ligands to cell surface molecules

Tolerance induction or immunosupression to prevent in particular Graft-versus-Host-Disease (GvHD) by short-term pre-incubation of transplanted cell suspensions, tissues or organs coated with ligands to cell surface molecules

机译：耐受诱导或免疫抑制，特别是通过短期预孵育移植的细胞悬浮液，被表面配体包被有配体的组织或器官来预防尤其是移植物抗宿主病（GvHD）

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摘要

The present invention relates to, among others, an in vitro method of modifying a cell graft containing immune cells comprising the steps of incubating a cell graft containing immune cells with an anti CD4 antibody wherein said incubating is carried out for from 1 minute to 7 days, b) removing unbound antibody from said graft; as well as to corresponding modified grafts and uses.

机译：本发明尤其涉及一种修饰包含免疫细胞的细胞移植物的体外方法，该方法包括以下步骤：将包含免疫细胞的细胞移植物与抗CD4抗体一起孵育，其中进行所述孵育。 1分钟至7天，b）从所述移植物中除去未结合的抗体;以及相应的改良嫁接物和用途。 展开▼

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公开/公告号EP2471543A1

专利类型

公开/公告日2012-07-04

原文格式PDF

申请/专利权人 FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;UNIVERSITÄT LEIPZIG;
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申请/专利号EP20100015236

发明设计人 FRICKE STEPHAN;EMMRICH FRANK;HILGER NADJA;
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申请日2010-12-02

分类号A61K35/28;C07K16/28;A61P37/06;C12N5;

国家 EP

入库时间 2022-08-21 17:12:19

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专利

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1. 用于组织或器官移植物诱导T细胞耐受的方法 [P] . 中国专利： CN1134266C . 2004.01.14

2. 用于组织或器官移植物诱导T细胞耐受的方法 [P] . 中国专利： CN1150760A . 1997-05-28

3. TOLERANCE INDUCTION OR IMMUNOSUPRESSION TO PREVENT IN PARTICULAR GRAFT-VERSUS-HOST-DISEASE (GVHD) BY SHORT-TERM PRE-INCUBATION OF TRANSPLANTED CELL SUSPENSIONS, TISSUES OR ORGANS COATED WITH LIGANDS TO CELL SURFACE MOLECULES [P] . 世界知识产权组织专利： WO2012072268A2 . 2012-06-07

机译：通过短期预移植已移植的细胞悬浮液，组织或有机物包被到细胞表面分子上的容忍诱导或免疫抑制来预防特定的移植物抗宿主病（GVHD）

4. TOLERANCE INDUCTION OR IMMUNOSUPPRESSION TO PREVENT IN PARTICULAR GRAFT-VERSUS-HOST-DISEASE (GVHD) BY SHORT-TERM PRE-INCUBATION OF TRANSPLANTED CELL SUSPENSIONS, TISSUES OR ORGANS COATED WITH LIGANDS TO CELL SURFACE MOLECULES [P] . 欧洲知识产权局专利： EP3351255A1 . 2018-07-25

机译：通过短期预移植已移植的细胞悬浮液，组织或有机物包被到细胞表面分子上的容忍诱导或免疫抑制，防止特定的移植物抗宿主病（GVHD）

5. Silenced anti-CD28 antibodies and use thereof for inducing T-cell tolerance, providing immunosupression and treating organ or tissue transplant rejection [P] . NZ526569A . 2005-07-29

机译：沉默的抗CD28抗体及其在诱导T细胞耐受，提供免疫抑制和治疗器官或组织移植排斥反应中的用途

1. Deletion of donor-reactive cells followed by stem cell transplantation in recipients treated with total lymphoid-irradiation as a means for induction of transplantation tolerance to organ allografts and xenografts. [J] . Slavin S, Gurevitch O, Zhu J, Transplantation Proceedings . 1998,第8期

2. Induction of mixed chimerism using combinatory cell-based immune modulation with mesenchymal stem cells and regulatory T cells for solid-organ transplant tolerance [J] . ImK.-I., ParkM.-J., KimN., Stem cells and development . 2014,第19期

3. Favorable Chronic Graft-Versus-Host-Disease (GVHD), Event-Free (EFS), and Overall Survival (OS) Rates Following Partially CD3-Depleted Alternative Donor Peripheral Stem Cell Transplantation (PSCT) for Pediatric Hematologic Malignancies [J] . Seif Alix E., Li Yimei, Aplenc Richard, Biology of blood and marrow transplantation: journal of the American Society for Blood and Marrow Transplantation . 2016,第3Suppla1期

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6. Induction of Mixed Chimerism Using Combinatory Cell-Based Immune Modulation with Mesenchymal Stem Cells and Regulatory T Cells for Solid-Organ Transplant Tolerance [O] . Keon-Il Im, Min-Jung Park, Nayoun Kim, -1

7. Tolerance induction in B lymphocytes but thymus-dependent antigens. T cells may abrogate B-cell tolerance induction by prevent an antibody response [O] . 1975

1. 供者凋亡细胞预输注诱导同种器官移植免疫抑制的实验研究 [A] . 陈建锋 . 2001