TOLERANCE INDUCTION OR IMMUNOSUPPRESSION TO PREVENT IN PARTICULAR GRAFT-VERSUS-HOST-DISEASE (GVHD) BY SHORT-TERM PRE-INCUBATION OF TRANSPLANTED CELL SUSPENSIONS, TISSUES OR ORGANS COATED WITH LIGANDS TO CELL SURFACE MOLECULES

摘要

The present invention relates to an anti human CD4-antibody comprising a heavy chain immunoglobulin variable domain (VH) and a light chain immunoglobulin variable domain (VL), wherein at least one T cell epitope located outside the CDRs of said immunoglobulin variable domains is removed from said immunoglobulin variable domains. Preferably, the specificity and mode of action of the anti-CD4 antibodies are not affected by the modification(s).