METAL NANOPARTICLE ASSOCIATED WITH CHITOSAN OR BPEI, RNAI, AND RAMAN DYE, AND METHODS OF ANALYSING EFFICIENCY OF ITS TRANSFECTION INTO CELL AND IDENTIFYING LOCATION OF IT IN CELL BY USING IT

摘要

PURPOSE: A method for measuring RNA interference delivery efficiency and position using RNAi, and chitosan, or BPEI metal nanoparticle complex is provided to treat lung cancer. CONSTITUTION: A method for measuring delivery efficiency of delivery drug-captured metal nano complex comprises: a step of contacting the metal nanoparticle complex to cells; a step of measuring the cell by z-depth dependent confocal SERS(surface enhanced raman scattering) after predetermined time; and a step of comparing the absorption of the intracellular metal nanoparticles with a control group to measure delivery efficiency.