METHOD FOR SUPPRESSING ADAMTS-5 ACTIVATION USING KOREAN BAEKJEOLYUSIN-TANG MEDICINE AND AN ACTIVE COMPONENT THEREOF

摘要

PURPOSE: A method for treating degenerative arthritis using traditional Korean Baekjeolyusin-tang medicine and an active component (berberine) thereof is provided to suppress ADAMTS-5 activation and expression for the prediction, diagnosis, and treatment of degenerative arthritis.;CONSTITUTION: A method for suppressing ADAMTS-5 comprises a step of applying Baekjeolyusin-tang medicine in which berberine is an active component, to chondrocytes in which inflammation was promoted by interleukin-1beta. Cortex Phellodendri contains berberine. A method for suppressing aggrecan comprises a step of suppressing ADAMTS-5 activation. An ADAMTS-5 inhibitor contains Baekjeolyusin-tang medicine or berberine.;COPYRIGHT KIPO 2012