ENANTIOSELECTIVE MANUFACTURING METHOD OF METHYL 2-(1-HYDROXY)-BUTA-2,3-DIENOLATE DERIVATIVES AND METHOD FOR PREPARING SYLVONE USING THE SAME

摘要

PURPOSE: An enantioelective method for preparing 2-(1-hydroxy)-buta-2,3-dienolate derivatives is provided selectively prepare enantiomers. CONSTITUTION: An enantioelective method for preparing optically active methyl 2-(1-hydroxy)-buta-2,3-dienolate derivatives comprises: a step of reacting a compound of chemical formula 1 with tribromoborane of chemical formula 2(BBr_3) to prepare a compound of chemical formula 3; a step of reacting the compound of chemical formula 3 with compounds of chemical formulas 4 and 5(i-Pr_2NCH_2CH_3); and a step of adding a compound of chemical formula 6(R-CHO) to prepare a compound of chemical formula 7.