Composition for protecting damage of auditory cells comprising glycogen synthase kinase-3 inhibitor as an active ingredient

摘要

The invention cell damage hearing protection compositions comprising a glycogen synthase kinase inhibitor as an active ingredient -3 relates to, and more particularly the present invention is a GSK-3 (Glycogen synthase kinase-3) hearing protection cell damage a composition comprising an inhibitor as the active ingredient, cisplatin, and GSK-3 (Glycogen synthase kinase-3) an active ingredient of the inhibitor relates to a method for screening the hearing cell injury prevention and mitigation of the compositions and formulations for cisplatin administration for the prevention and treatment of cancer comprising a. The present invention suppresses the apoptosis inhibitor of GSK-3 is induced by cisplatin, and caspase-3, caspase reduces the activity of the caspase-9 and -8, Cortina auditory cells in vivo, such as engine or the cochlea said the captain of Sikkim damage. Therefore, GSK-3 inhibitors of the present invention, hearing loss due to the damage of the auditory cells, hearing loss, tinnitus, as well as be used for the purpose of prevention and the like, cisplatin and GSK-3 for composition of a new anti-cancer composition comprising an inhibitor there is an effect that can be provided.