METHOD OF IDENTIFYING AGENTS WHICH MODULATE THE ACTIVITY OF CALCIUM-ACTIVATED CHLORIDE CHANNEL

摘要

The present invention is SEQ ID NO: 1 or SEQ ID NO: 1, or more amino acids having an amino acid sequence identity and 90% Identification method is composed of a sequence of a medicament for modulating the activity of a protein across the plasma membrane chloride ion transport, (a) exposing the drug to cells expressing the protein; And (b) comprises the step of measuring the degree of chloride ion transport in the exposed cell, wherein the expression, but the drug has a chloride ion transport protein is the amount of the drug is changed compared to control cells not exposed to the protein is related to the identification method, characterized in that the active, which indicates that the drug can be adjusted. Agents identified by the above method may be used for the prevention or treatment of various diseases caused by an abnormal function of calcium activated chloride channel. ;