Methods for identifying agents that modulate the activity of calcium-activated chloride channels

摘要

The present invention is an agent having an amino acid sequence at least 90% identity with SEQ ID NO: 1, or represented by the amino acid sequence of SEQ ID NO: 1, to modulate the activity of a protein to transport of chloride ions across the cell membrane A method of identifying, and it is exposed to the agent to cells expressing (a) the protein; measuring the chloride ion transport level in the cell and is (b) exposure, where the expression of the protein and which method includes indicating an agent capable of change in chloride ion transport level compared to control cells not exposed to Suruga active substance, modulating the activity of the protein. Agent identified by this method can be used for the prevention or treatment of various diseases caused by the dysfunction of calcium-activated chloride channel.