COMPOUNDS FOR USE IN VISUALIZATION, DIAGNOSTICS AND / OR TREATMENT OF DISEASES OF THE CENTRAL NERVOUS SYSTEM OR TUMORS

摘要

1. The compound of formula Ia! ! or formula Ib! ! where W is selected from the group consisting of! —C (U1) (U2) —C≡CH and cyclopropyl, U1 and U2, which are independently selected from hydrogen and deuterium; ! A is selected from the group consisting of substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, such as furanyl, (C1-C10) alkyl, G4- (C2-C4) alkynyl, G4- (C1-C4) alkoxy, (G4- ( C1-C4) alkyl) aryl, (G4- (C1-C4) alkoxy) aryl, (G4- (C1-C4) alkyl) apyl, and (G4- (C1-C4) alkoxy) apyl, where preferably said heteroaryl is furanil yourself! G1, G2, G3 and G4 in formula Ia and formula Ib are independently and individually, in each case, selected from the group consisting of hydrogen, (C1-C4) alkyl, preferably methyl, L, and - (C1-C6) alkyl -L,! provided that it is precisely one of G1-G4 in formula Ia that is selected from L and - (C1-C6) alkyl-L, and! provided that it is precisely one of G3 and G4 in formula Ib that is selected from L and! - (C1-C6) alkyl-L,! L is a leaving group, or L is F, preferably 18F or 19F, where, preferably, if L is 19F, said compound contains precisely one 19F atom that is attached to the sp3 hybridized carbon atom,! where n is an integer from 0 to 6, preferably 1-3, more preferably 1-2,! and where m is an integer from 0 to 4, preferably 0 to 2, more preferably 0-1,! and where e and f are an integer from 0 to 1, provided that at least one of e and f is 1, including all isomeric forms of said compound, which include, but are not limited to, enantiomers and diastereoisomers, so same as racemic mixtures! and any pharmaceutically acceptable salt, ester, amide, complex compound or prodrug, respectively. !