AMORPHIC FORM OF A STEROID ANTI-INFLAMMATORY COMPOUND, METHOD FOR PRODUCING IT, PHARMACEUTICAL COMPOSITION AND METHOD FOR TREATING OR PREVENTING DISEASES OR SYMPTOMS OF SKIN DISEASES OR MUCH

摘要

1. Amorphous form of the steroidal anti-inflammatory compound (I) corresponding to the formula:! ! 2. The amorphous form according to claim 1, which is a therapeutic agent in the treatment or prevention of diseases or symptoms of diseases of the skin or mucous membranes. ! 3. The amorphous form according to claim 2, which is a therapeutic agent in the treatment of scabies, atopic dermatitis, contact dermatitis, seborrheic dermatitis, dermatosis, eczema, epidermolysis bullosa, erythema, usura, peeling of the skin, exudation, inflammation, Wilson's lichen, red lichen, the formation of papules, itching, diaper rash, trichophytosis of the perineum, psoriasis and growths on the skin. ! 4. The method of obtaining the amorphous form according to claim 1, comprising dissolving the compound (I) in dioxane, filtering the solution and recovering the resulting amorphous form of the compound (I) by lyophilization at a temperature of from -5 to 5 ° C. ! 5. The method according to claim 4, in which the lyophilization is carried out at a temperature of from -2 to 2 ° C. ! 6. The method according to claim 5, in which the lyophilization is carried out at a temperature of 0 ° C. ! 7. The use of the amorphous form according to claim 1 for the preparation of a pharmaceutical composition in the treatment or prophylaxis of diseases or symptoms of diseases of the skin or mucous membranes. ! 8. The use according to claim 7, in which the pharmaceutical composition is a therapeutic agent for the treatment of scabies, atopic dermatitis, contact dermatitis, seborrheic dermatitis, dermatosis, eczema, epidermolysis bullosa, erythema, usurization, skin peeling, exudation, inflammation, depriving Wilson, red depriving, the formation of papules, itching, diaper rash, trichophytosis of the perineum, psoriasis and growths on the skin. ! 9. The use according to claim 7 or 8, in which the composition is performed