METHOD OF PREDICTING METASTASIS OF GASTRIC CANCER PATIENTS

摘要

FIELD: medicine.;SUBSTANCE: patients suffering stomach cancer are examined for a marker of proliferative activity Ki-67 and markers of apoptosis p53 and bcl-2. That is combined with immunohistological analysis to determine the absolute values in signet ring cell carcinoma: p53 - 10%, bcl-2 -10%, Ki-67 - 12%; in carcinoma simplex: p53 - 13%, bcl-2 11%, Ki-67 - 9%; in adenocarcinoma: p53 - 10%, bcl-2 - 9%, Ki-67 - 12% enabling to predict the onset of metastases in lymph nodes. The values p53 - 6%, bcl-2 -5%, Ki-67 - 10% provide to predict the absence of metastatic lesions in lymph nodes.;EFFECT: these predictors enable predicting an outcome of the disease, a survival rate and a probability of metastases in the untreated patients with planning of therapeutic actions.;1 tbl, 3 ex, 5 dwg