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FATTY ACID SYNTHETASE, POLYNUCLEOTIDE CODING IT AND APPLICATION THEREOF
FATTY ACID SYNTHETASE, POLYNUCLEOTIDE CODING IT AND APPLICATION THEREOF
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机译:脂肪酸合成酶,多核苷酸编码及其应用
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摘要
FIELD: medicine.;SUBSTANCE: what is described is fatty acid synthetase of a sequence presented in the description. What is specified is a polynucleotide coding such synthetase. What is presented is a vector containing such polynucleotide. Besides, what is also described is a transformed microbial organism containing such vector or polynucleotide. The transformed microbial organism is used to produce fatty acids. What is offered is a method for producing a lipid or a fatty acid that involves transformant cell culture followed by recovering the lipid or the fatty acid from such cells. What is described is a method for assessment of ability to form fatty acids based on the measurement of an expression level of fatty acid synthetase having a nucleotide sequence of specified polynucleotide. Also, there is presented a method for selection of microbial lipid-producing organisms that is based on the comparison of the expression levels of specified gene in a reference and tested microbial organism.;EFFECT: invention provides producing high-yield fatty acids.;17 cl, 1 dwg, 2 tbl, 1 ex
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机译:领域:药物;物质:描述的是描述中呈现的序列的脂肪酸合成酶。所指定的是编码这种合成酶的多核苷酸。提出了一种包含这种多核苷酸的载体。此外,还描述了包含此类载体或多核苷酸的转化的微生物。转化的微生物用于生产脂肪酸。提供一种产生脂质或脂肪酸的方法,该方法涉及转化细胞培养,然后从此类细胞中回收脂质或脂肪酸。描述了一种基于具有特定多核苷酸的核苷酸序列的脂肪酸合成酶的表达水平的测量来评估形成脂肪酸的能力的方法。此外,还提供了一种选择微生物产生脂质的方法的方法,该方法基于比较参考基因和测试微生物中特定基因的表达水平。效果:本发明提供了产生高产率脂肪酸的方法。17 cl,1 dwg,2 tbl,1 ex
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