METHOD OF CORRECTING ENDOTHELIAL DYSFUNCTION BY L-NORVALIN IN CASE OF ADMA-LIKE MODEL OF GESTOSIS

摘要

FIELD: medicine.;SUBSTANCE: modeling of ADMA-like model of gestosis in laboratory pregnant rats of Wistar line is carried out by daily introduction of inhibitor of NO-synthase L-NAME in dose 25 mg/kg from 14 to 20 day of pregnancy. Correction of endothelial dysfunction is performed by L-norvalin, which at the background of modeling is introduced intragastrically daily for 7 days in dose 10 mg/kg once per day.;EFFECT: method leads to expressed dysfunction correction under conditions of specific mechanisms of pathological process course in pregnant women.;1 ex