METHOD FOR ENDOTHELIAL DYSFUNCTION CORRECTION WITH POLYVITAMIN-MINERAL COMPLEX IN ADMA-LIKE GESTOSIS MODELS IN EXPERIMENT

摘要

FIELD: medicine.;SUBSTANCE: ADMA-like gestosis model is experimentally reproduced in laboratory pregnant Wistar rats by the daily intraperitoneal introduction of L-nitro-arginine-methyl ester 25 mg/kg for 7 days. The endothelial dysfunction is corrected by the vitamine-mineral preparation 'Complivit Trimestrum Trimester 3' which with underlying simulation is introduced intragastrically in a dose of 0.084 tablet/kg/day for 7 days.;EFFECT: method provides effective endothelial dysfunction correction in pregnant females ensured by an endothelioprotective effect of vitamins under specified experimental conditions and dosages.;1 ex