or their pharmaceutically acceptable salts wherein R1, R2, R3 and R4 are presented in the description and exhibit substantial COMT inhobotory activity. Besides, the present invention described pharmaceutical compositions inhibiting catechol-O-transferase activity which contain the compound or its pharmaceutically acceptable salt as an active ingredient, and a pharmaceutically acceptable carrier.;EFFECT: there are declared pharmaceutical combinations for treatment or prevention of Parkinson's disease which contain (1) the pharmaceutical composition containing the compound under any cl 1-8 or its pharmaceutically acceptable salt and the pharmaceutically acceptable carrier, and (2) at least one compound specified in L-dope or carbidole.;10 cl, 9 ex, 17 tbl"/>
公开/公告号RU2459812C2
专利类型
公开/公告日2012-08-27
原文格式PDF
申请/专利权人 KISSEI FARMASJUTIKAL KO. LTD.;
申请/专利号RU20100125903
发明设计人 ISIKAVA TAKEKHIRO (JP);INOUE KHITOSI (JP);KOBAJASI SATOKO (JP);JOSIDA MASAKO (JP);SIOKHARA KHIROAKI (JP);UENO JASUNORI (JP);TANAKA NOBUJUKI (JP);
申请日2008-12-22
分类号C07D271/06;A61K31/4245;A61K31/427;C07D413/04;A61P25/16;
国家 RU
入库时间 2022-08-21 17:05:57