METHOD FOR DETERMINING COEFFICIENT OF REDUCTION OR Kt/V VALUE IN REPLACEMENT RENAL THERAPY AND APPARATUS FOR IMPLEMENTING SAID METHOD

摘要

FIELD: medicine.;SUBSTANCE: group of inventions refers to medicine and is used for monitoring the effectiveness of the replacement renal therapy. The monitoring is implemented by the values of a coefficient of reduction RR and the Kt/V value. The concentration is measured by at least one waste product with the use of spectrophotometry in discharged fluid used for the replacement therapy. The discharged fluid circulates in a closed loop relatively to blood supplied from an apparatus for renal function replacement until a spectrophotometric value of the discharged fluid reaches the constant A_BO. The coefficient RR or the Kt/V value is determined by equations RR = 1-A_B(t)/A_BO or Kt/V = -ln(A_B(t)/A_BO), wherein A_B(t) is the spectrophotometric value of the discharged fluid used for the replacement renal therapy at the moment of time t of a procedure of the replacement therapy started after recirculation of the discharged fluid, K is an effective clearance of the waste product, V is a volume of distribution of the waste product, what is disclosed is an apparatus used for implementing the method and the apparatus for renal function replacement, the external blood circulation loop, a channel and valve system for conducting the replacement therapy and a measuring device.;EFFECT: invention provides adequacy control of the replacement renal therapy.;29 cl, 6 dwg