Determining efficacy or non efficacy of doxorubicin (alone or in combination with other medications) for patients with tumor, e.g. breast cancer or ovarian cancer, comprises using DNA methylation profile before or during therapy

摘要

Determining the efficacy or non efficacy of doxorubicin (alone or in combination with other medications) for patients with tumor, preferably gynecological tumor, preferably breast cancer or ovarian cancer, comprises using DNA methylation profile before or during therapy. The efficacy or non efficacy of doxorubicin is tested with the help of a methylation profile, which is recorded at least by a CpG-probe microarray (biochip, gene chip, DNA chip). Determining the efficacy or non efficacy of doxorubicin (alone or in combination with other medications) for patients with tumor, preferably gynecological tumor, preferably breast cancer or ovarian cancer, comprises using DNA methylation profile before or during therapy. The efficacy or non efficacy of doxorubicin is tested with the help of a methylation profile, which is recorded at least by a CpG-probe microarray (biochip, gene chip, DNA chip), where the methylation profile of at least one of the CpG islands (CGIs) is determined in at least a region of appendix table S1 (as shown in the specification) from at least one of the genes: ATP-binding cassette sub-family B (MDR/TAP) member1 (ABCB1), adenomatous polyposis coli gene (APC), breast cancer1 early onset (BRCA1), cadherin1, type1, E-cadherin (epithelial) (CDH1), DnaJ (Hsp40) homolog, subfamily C, member 15 (DNAJC15), estrogen receptor 1 (ESR1), glutathione S-transferase pi 1 (GSTP1), hypermethylated in cancer1 (HIC1), insulin-like growth factor binding protein 3 (IGFBP3), plasminogen activator, urokinase (PLAU), RAB6C, member RAS oncogene family (RAB6C), Ras association (RalGDS/AF-6) domain family member 1 (RASSF1), sulfatase 2 (SULF2) or transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) (TGM2). - ACTIVITY : Cytostatic. No biological data given. - MECHANISM OF ACTION : None given.