1H-Pyrazolo[3,4-b]pyridine compounds (I) and their N-oxides, salts, solvates, salts of N-oxides or solvates of N-oxides and salts, are new. 1H-Pyrazolo[3,4-b]pyridine compounds of formula (I) and their N-oxides, salts, solvates, salts of N-oxides or solvates of N-oxides and salts, are new. A : N or CR 3; R 3H, D, F, CHF 3, CF 3, (1-4C)-alkyl, cyclopropyl or cyclobutyl; L : a-CR4AR4B-(CR5AR5B) p-b; a : connection point at carbonyl group; b : connection point to pyrimidine or triazine ring; p : 0-2; either R4A, R5A : H, F, (1-4C)-alkyl or OH; and R4B, R5B : H, F, (1-4C)-alkyl or CF 3; or R4AR4BC : an oxy group, 3-6 membered carbocyclic ring or 4-6 membered heterocyclic ring; R 1H or F; and R 2benzyl substituted by 1-3 F. Independent claims are included for: (1) the preparation of (I); and (2) a medicament comprising (I) in combination with an inert, non-toxic auxiliary agent and a further active agent comprising organic nitrate, nitiric oxide donors, cGMP-phosphodiesterase inhibitors, anti-thrombotic active agents, blood pressure lowering agents and/or fat metabolism modifying agent. [Image] - ACTIVITY : Cardiant; Antianginal; Muscular-Gen.; Vasotropic; Thrombolytic; Antiarteriosclerotic; Antiarrhythmic; Antiparkinsonian; Antiinflammatory; Endocrine-Gen.; Antilipemic; Anorectic; Uropathic; Nephrotropic; Neuroprotective; Hypotensive; Respiratory-Gen.; CNS-Gen.; Nootropic; Cerebroprotective; Anticonvulsant; Antidepressant; Antibacterial; Immunosuppressive; Gastrointestinal-Gen.; Antiarthritic; Antirheumatic; Vulnerary; Hepatotropic; Virucide; Osteopathic; Ophthalmological. - MECHANISM OF ACTION : Guanylate cyclase stimulator. The ability of (I) to stimulate guanylate cyclase was tested using recombinant guanylate cyclase reporter cell line. The results showed that 2-[1-(2-fluorobenzyl)-1H- pyrazolo[3,4-b]pyridin-3-yl]-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one exhibited a minimal effective concentration of 0.01 mu M.
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