Identification of acidic heterocycle-substituted 1H-pyrazolo[3,4-b] pyridines as soluble guanylate cyclase stimulators

GriebenowN.; SchirokH.; MittendorfJ.; StraubA.; FollmannM.; StaschJ.-P.; KnorrA.; SchlemmerK.-H.; RedlichG.

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Identification of acidic heterocycle-substituted 1H-pyrazolo[3,4-b] pyridines as soluble guanylate cyclase stimulators

机译：鉴别酸性杂环 - 取代的1H-吡唑啉[3,4-B]吡啶作为可溶性胍基环化酶刺激器

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《Bioorganic and Medicinal Chemistry Letters》 |2013年第5期|共4页
作者
GriebenowN.; SchirokH.; MittendorfJ.; StraubA.; FollmannM.; StaschJ.-P.; KnorrA.; SchlemmerK.-H.; RedlichG.;
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作者单位

Bayer Pharma AG Global Drug Discovery Medicinal Chemistry Wuppertal D-42096 Wuppertal Germany;

Bayer Pharma AG Global Drug Discovery Medicinal Chemistry Wuppertal D-42096 Wuppertal Germany;

Bayer Pharma AG Global Drug Discovery Medicinal Chemistry Wuppertal D-42096 Wuppertal Germany;

Bayer Pharma AG Global Drug Discovery Medicinal Chemistry Wuppertal D-42096 Wuppertal Germany;

Bayer Pharma AG Global Drug Discovery Medicinal Chemistry Wuppertal D-42096 Wuppertal Germany;

Bayer Pharma AG Global Drug Discovery Cardiology Research D-42096 Wuppertal Germany;

Bayer Pharma AG Global Drug Discovery Cardiology Research D-42096 Wuppertal Germany;

Bayer Pharma AG Global Drug Discovery Research Pharmacokinetics D-42096 Wuppertal Germany;

Bayer Pharma AG Global Drug Discovery Research Pharmacokinetics D-42096 Wuppertal Germany;

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正文语种 eng
中图分类药学;
关键词
Acidic heterocycles; Carboxylic acid isosteres; Guanylate cyclase; SAR; Stimulator;

机译：酸性杂环;羧酸旁观者;胍酸盐环化酶;SAR;刺激器;

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1. Identification of acidic heterocycle-substituted 1H-pyrazolo[3,4-b] pyridines as soluble guanylate cyclase stimulators [J] . GriebenowN., SchirokH., MittendorfJ., Bioorganic and Medicinal Chemistry Letters . 2013,第5期

机译：鉴别酸性杂环 - 取代的1H-吡唑啉[3,4-B]吡啶作为可溶性胍基环化酶刺激器
2. Molecular Mechanisms Underlying Rat Mesenteric Artery Vasorelaxation Induced by the Nitric Oxide-Independent Soluble Guanylyl Cyclase Stimulators BAY 41-2272 [5-Cyclopropyl-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-4-ylamine] and [J] . Cleber E.Teixeira, Fernanda B.M.Priviero, R.Clinton Webb The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 2006,第1期

机译：一氧化氮非依赖性可溶性胍基环化酶刺激剂BAY 41-2272 [5-环丙基-2- [1-（2-氟苄基）-1H-吡唑并[3,4-b]吡啶]-诱导大鼠肠系膜血管舒张的分子机制3-基]嘧啶-4-基胺]和
3. Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5- carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT) [J] . ZhengX., BairK.W., BauerP., Bioorganic and Medicinal Chemistry Letters . 2013,第20期

机译：鉴定源自1H-吡唑并[3,4-b]吡啶-5-羧酸的酰胺作为有效的人烟酰胺磷酸核糖基转移酶（NAMPT）抑制剂
4. DEVELOPMENT OF A NOVEL BIOLUMINESCENT ASSAY FOR NITRIC OXIDE BY USING SOLUBLE GUANYLATE CYCLASE [C] . YOSHIHIRO SANO, MASAYUKI SEKI, SHIGEYA SUZUKI, The 15th International Symposium on Bioluminescence and Chemilminescence(第十五届生物发光和化学发光国际会议)论文集 . 2008

机译：可溶性胍盐环化酶法开发一种新型的生物发光法检测一氧化氮
5. Identification and characterization of a conserved soluble guanylate cyclase-like heme domain that discriminates between nitric oxide and oxygen. [D] . Karow, David Stanley. 2005

机译：鉴定和表征区分一氧化氮和氧的保守的可溶性鸟苷酸环化酶样血红素结构域。
6. The CNS-Penetrant Soluble Guanylate Cyclase Stimulator CY6463 Reveals its Therapeutic Potential in Neurodegenerative Diseases [O] . Susana S. Correia, Rajesh R. Iyengar, Peter Germano, 2021

机译：CNS-渗透溶解的胍基环化酶刺激剂CY6463揭示了神经变性疾病的治疗潜力
7. Novel bisphosphonates derived from 1H-indazole, 1H-pyrazolo[3,4-b]pyridine and 1H-pyrazolo[3,4-b]quinoline [O] . Teixeira, António P. S., Teixeira, Fátima C., Lucas, Carla, 2016

机译：衍生自1H-吲唑，1H-吡唑并[3,4-b]吡啶和1H-吡唑并[3,4-b]喹啉的新型双膦酸酯

Identification of acidic heterocycle-substituted 1H-pyrazolo[3,4-b] pyridines as soluble guanylate cyclase stimulators

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