Implant, useful as a stent, a sensor or an electrode, comprises a coating comprising functionalized arginine-glycine-aspartic acid peptidomimetic compounds

摘要

Implant comprises a coating, which is a functionalized arginine-glycine-aspartic acid (RGD) peptidomimetic compound (I) and/or a functionalized RGD peptidomimetic compound (II). Implant comprises a coating, which is a functionalized arginine-glycine-aspartic acid (RGD) peptidomimetic compound of formula (I) and/or a functionalized RGD peptidomimetic compound of formula (II). A : a coupling group comprising 1,4-phenylene diisothiocyanate, 1,4-phenylene diisocyanate, 1-isothiocyanato-4-isocyanatobenzene (all preferred), N,N'-carbonyldiimidazole and/or disulfosuccinimidyl tartrate; R : chitosan or polylysine; and n, m : 1-20, preferably 5. Independent claims are included for: (1) the preparation of the implant comprising coating a stent with a layer containing chitosan and/or polylysine, covalently coupling primary amine comprising chitosan and/or polylysine with the coupling group of a precursor of a functionalized RGD-peptidomimetic (I) of formula (III) and/or a precursor of a functionalized RGD-peptidomimetic (II) of formula (IV); and (2) the compounds (I)-(IV), where (III) is of formula (IIIa) or (IIIb) and (IV) is of formula (IVa) or (IVb). [Image] [Image] [Image] [Image] [Image] [Image] [Image] [Image].