OPTIMIZATION OF THE SYNTHESIS AND ACCUMULATION OF LIPIDS

摘要

The present invention relates to a new mutant strain of yeast, particularly a strain Yarrowia lipolytica, capable of accumulating a large amount of lipids. The strain is deficient in the beta-oxidation of fatty acids and overexpresses the GPD1 gene. Preferably, the mutant strains which do not express the GUT2 gene and which are deficient for the beta-oxidation of the fatty acids do not express the POX 2 to POX 5 genes, most preferably the POX 1 to 6 genes. another object is a process for obtaining the strains according to the invention and the use of said strains in the production of lipids.