The method of in vitro for determining the intracellular free magnesium deficiency in an individual by measuring the expression rate of the cells Mg2 + transporter gene

摘要

Method of in vitro to determine the presence or absence of the individual intracellular free magnesium deficiency in humans is disclosed. The method, in at least one of the cell Mg ²⁺ cell sample of the individual expression rate of the transporter gene that shows a direct correlation between the expression rate and intracellular free magnesium ion concentration [Mg ^2+]_i a step of measuring, and it is implemented by the resulting step of comparing the expression rate and the reference value, increased expression rate as compared to the reference value indicates that the individual suffers from intracellular free magnesium deficiency. Suitable Mg ²⁺ transporter gene include CNNM2, SLC41A1 and SLC41A3.