首页>
外国专利>
Protein binding domain that stabilizes functional conformational state of GPCR and uses thereof
Protein binding domain that stabilizes functional conformational state of GPCR and uses thereof
展开▼
机译:稳定GPCR功能构象状态的蛋白结合结构域及其用途
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention relates to the field of GPCR structure biology and signaling. In particular, the present invention relates to protein binding domains directed against or capable of specifically binding to a functional conformational state of a G-protein coupled receptor (GPCR). More specifically, the present invention provides protein binding domains that are capable of increasing the stability of a functional conformational state of a GPCR, in particular increasing the stability of a GPCR in its active conformational state. The protein binding domains of the present invention can be used as a tool for the structural and functional characterization of G-protein coupled receptors bound to various natural and synthetic ligands, as well as for screening and drug discovery efforts targeting GPCRs. Moreover, the invention also encompasses the diagnostic, prognostic and therapeutic usefulness of these protein binding domains for GPCR-related diseases.
展开▼